Methandienone is an anabolic steroid banned from use by FDA under controlled substances act. Dianabol has been very popular in bodybuilders until its ban to increase strength and volume of their muscles. Dianabol acts strongly on androgen receptors and exerts its effects by protein synthesis and glycogen breakdown to increase muscle mass in short space of time. Dianabol produces estrogen as end product so water retention is also one of the contributors towards weight gain and increased volume. Dianabol effective dose is15-50 mg/day in men and its active life is 6-8 hours. Dianabol is excreted through kidneys and detection time in urine is 5-6 weeks. Until the ban Dianabol has been used as tonic by bodybuilders. Probably, Dianabol is effective in treatment of senile postmenopausal osteoporosis. Dianabol was also recommended in those individuals who are suffering from condition called pituitary deficient dwarfism. Dianabol was also used in those individuals who have weakened bones and always complain for exhaustion after small running and prolong walking. Still, Dianabol is prepared in large quantity in those countries where drugs regulations are weak and is used in human as well as in veterinary patients of the conditions described above.
Since Dianabol’s half-life time is only – hours, application at least twice a day is necessary to achieve a somewhat even concentration of the substance in the blood. It is recommended that the tablets be taken during meals so that possible gastrointestinal pains can be avoided. Dianabol reaches the blood after 1-3 hours. A simple application of only 20 mg results in a 5-fold increase in the average testosterone concentration in the male. Women should not use Dianabol because, due to its distinct androgenic component, considerable virilization symptoms can occur. Although Dianabol has many potential side effects, they are rare with a dosage of 20 mg/day. Since Dianabol is I7-alpha alkylated it causes a considerable strain on the liver. In high dosages and over a longer period of time, Dianabol is liver toxic. Even a dosage of only 20 mg/day can increase the liver values; after discontinuance of the drug, however, the values return to normal. Since Dianabol quickly increases the body weight due to high water retention, a high blood pressure and a faster heartbeat can occur, sometimes requiring the intake of an antihypertensive drug such as Catapresan. Additive intake of Nolvadex and Proviron might be necessary as well, since Dianabol strongly converts into estro-gens and in some athletes causes gynecomastia (“bitch tits”) or worsens an already existing condition. Because of the strongly androgenic component and the conversion into dihydrotestosterone, Dianabol, in some athletes, can trigger a serious acne vulgaris on the face, neck, chest, back, and shoulders since the sebaceous gland function is stimulated. If a hereditary predisposition exists Dianabol can also accelerate a possible hair loss which again can be explained by the high conversion of the substance into dihydrotestosterone. Another disadvantage is that, after discontinuance of the compound, a considerable loss of strength and mass often occurs since the water stored during the intake is again excreted by the body. In high dosages of 60 mg +/day aggressive behavior in the user can occasionally be observed which, if it only refers to his workout, can be an advantage. In order to avoid uncontrolled actions, those who have a tendency to easily lose, their temper should be aware of this characteristic when taking a high D-bol dosage. Despite all of these possible symptoms Dianabol instills in most athletes a “sense of well being anabolic” which improves the mood and appetite and in many users, together with the obtained results, leads to an improved level of consciousness and a higher self-confidence.