In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.  In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed.  In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected. 
In bodybuilding, Drostanoloneis especially popular for its properties: the drug has a diuretic effect, thereby achieving the best relief and vascularity and muscle definition. Drostanolone is valued by athletes who want to increase the density and hardness of the muscles, often used in the run-up to the competition. You can achieve excellent muscle look, due to the lipolytic effect of the drug. As practice shows, the administration rate of Drostanoloneis able to reduce body weight by 6-8% of the original, which is an excellent result (without the use of growth hormone and peptides).
Some bodybuilders and athletes use trenbolone for its muscle-building and otherwise performance-enhancing effects. [ citation needed ] Such use is illegal in the United States and many other countries. The DEA classifies trenbolone as a Schedule III controlled substance under the Controlled Substances Act .  Trenbolone is classified as a Schedule 4 drug in Canada  and a class C drug with no penalty for personal use or possession in the United Kingdom .  Use or possession of steroids without a prescription is a crime in Australia .  The infamous "duchess" cocktail administered to Russian athletes at the Sochi Winter Olympics consisted of oxandrolone , metenolone , and trenbolone.