When switching a patient from immediate-release capsules to Eskalith CR Controlled-Release Tablets, give the same total daily dose when possible. Most patients on maintenance therapy are stabilized on 900 mg daily, ., Eskalith CR 450 mg . When the previous dosage of immediate-release lithium is not a multiple of 450 mg, ., 1,500 mg, initiate Eskalith CR at the multiple of 450 mg nearest to, but below , the original daily dose, ., 1,350 mg. When the 2 doses are unequal, give the larger dose in the evening. In the above example, with a total daily dose of 1,350 mg, generally 450 mg of Eskalith CR should be given in the morning and 900 mg of Eskalith CR in the evening. If desired, the total daily dose of 1,350 mg can be given in 3 equal 450-mg doses of Eskalith CR. These patients should be monitored at 1- to 2-week intervals, and dosage adjusted if necessary, until stable and satisfactory serum levels and clinical state are achieved.
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