Nutritional zinc deficiency has been associated with decreased wound healing by damaging epidermal cells and altering polymorphonuclear cell function, natural killer cell function, and complement activity. 41 , 42 , 43 Delayed healing after burns because of micronutrient deficiency has been reported. 55 Supplementation with selenium, copper, and zinc has been associated with increased circulating plasma and skin tissue ions, enhanced antioxidant status, and improved clinical outcomes in a small trial (n = 21) among burn patients. 56 A Cochrane systematic review found no evidence to support the role of oral zinc sulfate in healing chronic venous ulcers. 57 , 58
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