Estrogenic side effects with this type of AAS are not necessary to mention, since it does not convert to estrogen. Therefore, the formation of gynecomastia, water retention and fat wrapping are not occurrence flaws. Androgenic side effects occur but to a much greater extent. It has profound effects on the scalp, which often causes hair loss, but not least relatively strong and extensive acne on the scalp, which often tends to grow to painful and scar-leaving ulcers. Also often mentioned is prostate enlargement. Noted is also slightly elevated blood pressure. It reduces the production of testosterone, like all anabolic androgenic steroids, it belongs among those with only a mild effect in this regard. Theoretically, it has a very strong potential to stimulate aggression, because it somehow negatively affects the central nervous system, but this is rather showing in women, in men it remains questionable. In long-term use, often observed are sleep disorders. Although it was used as a support drug for the treatment of cholesterol levels, in the long-term abuse decrease in HDL (good) and increase in LDL (bad) cholesterol.
Masteron in particular may possibly exhibit even worse effects on the negative cholesterol changes it imparts on the human body. This is due to Masteron’s aromatase inhibiting and anti-estrogenic properties, as the reduction of Estrogen levels below normal physiological levels has been demonstrated in studies to impart an even worse impact on cholesterol profiles than when anabolic steroids are administered alone without an aromatase inhibitor. Testosterone in particular has demonstrated in one clinical study to have only a mild impact on HDL cholesterol after a 12 week period where 280mg of Testosterone Enanthate was administered weekly. The cholesterol profiles had later changed for the worse when an aromatase inhibitor was included, which resulted in a significant 25% drop in HDL cholesterol  . This must be remembered by any potential user of Masteron, and Estrogen levels must be closely monitored so as to ensure Masteron does not reduce Estrogen to the point whereby cholesterol profiles are impacted negatively.
Masteron will significantly suppress natural testosterone production making exogenous testosterone therapy important when using this steroid. Failure to include exogenous testosterone will lead most men to a low testosterone condition, which not only comes with numerous possible symptoms but is also extremely unhealthy.
As most will use Masteron in a cutting cycle, it’s very common not to want to use a lot of testosterone due to the high levels of estrogenic activity it can provide. If this is the case, you will find a low dose of 100-200mg per week of testosterone to be enough to combat suppression and give you the needed testosterone.
Once Masteron is discontinued and all exogenous steroidal hormones have cleared your system, natural testosterone production will begin again. Prior levels will not return to normal over night, this will take several months. Due to the slow recovery, Post Cycle Therapy (PCT) plans are often recommended. This will speed up the recovery greatly; however, it won’t bring your levels back to their peak, this will still take time. A PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise and significantly cut down on the total recovery time. This natural recovery does assume no prior low testosterone condition existed. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper supplementation practices.