I’ve been fighting shingles now for 6 weeks and I’m still suffering from pain where the shingles blisters were located. I started 15 billion probiotics midway thru this and was feeling better. I was taking 5 billion 3 times a day. A friend coaxed me to bump it up to 20 billion. So I did this and by the 3rd day I had a rash all over my head. I’ve since stopped and the rash has gone away. I really want to go back on it, but now I’m stuck with 20 billion capsules. Any ideas on breaking these capsules in half to take half in the morning then again at night? Or should I wait til after this shingle pain goes away? I’m sure I’m in toxic overload with having fibromyalgia and type 2 diabetes. What would u suggest I do? Thank you.
And, exacerbating these two age-related erosive events, some catabolites
of tryptophan can lead to the formation of mutagenic nitrosamines or
the activation of an immunosuppressive receptor (which is usually
triggered by toxicants such as xenobiotics), promoting carcinogenesis
(Mezrich, et al., 2010; Chung & Gadupudi, 2011).
The consumption of a supplement of tryptophan will likely nurture or augment these disastrous age-associated disease states, by raising injurious tryptophan derivatives (particularly in the presence of a vitamin B6 deficiency, an insufficiency of stomach acid, a magnesium deficit, and a vitamin B3 deficiency).
Furthermore, tryptophan side effects in regards to greater mortality were shown in animal experiments (., Catrina, et al., 2001) using melatonin, whereas the study authors cautioned:
“[...] melatonin had a deleterious effect on the survival rate raising the question whether it is correct to assume that the hormone shows lack of adverse reactions.” [emphasis added]
In regard to serotonin's involvement in the promotion of higher mortality, one of its anti-longevity effects is conceivably the reabsorption of phosphate (a pro-inflammatory chemical) by the kidneys since klotho, an anti-aging protein, facilitates the excretion of phosphate from the kidneys (Peat, Nov. 2012).
Since tryptophan, serotonin, and melatonin meddle with basic energy production in cells, and since metabolic efficiency and functionality decreases proportionally with aging (Fannin, et al., 1999; O'Toole, et al., 2010) due to various factors, it seems coherent in biological terms that these substances are less prevalent, thus less “essential” or needed, in older people, as a further decrease of an already suboptimal general metabolic working order will aggravate physiological function systematically, increase the risk for disease (as exemplified and foreshadowed with tryptophan side effects), promote the aging process, and explains the increased mortality related to the administration of these substances.
Several tryptophan side effects, such as tryptophan's carcinogenic activities, the deterioration of metabolic energy function, and the promotion of hypertension, can rather readily account for a greater death rate.
Note: The active ingredients in gynostemma are known as saponins. This large group of chemicals is characterized by their general ability to make soap-like suds when they are mixed with water and the mixture is shaken. Saponins may have many effects in the body, including positive ones such as improving immune function. Saponins may also have negative effects such as blocking the digestion of some nutrients. Gynostemma may contain over 80 different types of saponins. Because the content of saponins and other chemicals in gynostemma varies greatly depending on the species of the plant and the conditions under which it grows, standardizing gynostemma products is difficult. Standardization by the manufacturer should assure the same amount of active ingredient in every batch of the commercial preparation. Standardization of herbal products is not required by the . Food and Drug Administration (FDA), so not every gynostemma product that is available contains the same amounts of active ingredients.