Before treatment, the patient should be asked to identify a history of hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam antibiotics. In patients with increased sensitivity to penicillins, possible allergic cross-reaction with cephalosporin antibiotics. In exchange treatment is necessary to monitor the state functions of blood, liver and kidneys. In patients with severely impaired renal function requires adequate dosage adjustment, or increase the interval between taking the dose. To reduce the risk of adverse effects should take the drug during meals from the gastrointestinal tract.
It is possible the development of superinfection due to growth insensitive to proviron steroid microflora, which requires a corresponding change in antibiotic therapy.
In patients with impaired renal function, as well as high doses of the drug can seizures occur.
It is not recommended to use the drug in patients with suspected infektsionnny mononucleosis.
If you have antibiotic-associated colitis should immediately stop taking the drug Amoxiclav ® , see a doctor and begin appropriate treatment. Drugs inhibiting peristalsis are contraindicated in such situations.
In patients with reduced urine output crystalluria occurs very rarely. During the application of high doses of proviron steroid is recommended to take plenty of fluids and to maintain an adequate urine output in order to reduce the probability of formation of proviron steroid crystals.
Laboratory tests: high proviron steroid concentrations give a false positive reaction to glucose urine using Benedict’s reagent or Fehling’s solution.
It is recommended to use the enzymatic reaction with glucosidase.
Clavulanic acid can cause nespetsifcheskoe binding immunoglobulin G (IgG) with albumin and erythrocyte membranes, which leads to false positive results Coombs test.